HYDAMTIQ, a selective PARP‐1 inhibitor, improves bleomycin‐induced lung fibrosis by dampening the TGF‐β/SMAD signalling pathway

Idiopathic pulmonary fibrosis is a severe disease characterized by excessive myofibroblast proliferation, extracellular matrix and fibrils deposition, remodelling of lung parenchyma and pulmonary insufficiency. Drugs able to reduce disease progression are available, but therapeutic results are unsat...

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Опубликовано в: :J Cell Mol Med
Главные авторы: Lucarini, Laura, Durante, Mariaconcetta, Lanzi, Cecilia, Pini, Alessandro, Boccalini, Giulia, Calosi, Laura, Moroni, Flavio, Masini, Emanuela, Mannaioni, Guido
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264150/
https://ncbi.nlm.nih.gov/pubmed/27704718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12967
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