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The Inhibitory Effects of HYDAMTIQ, a Novel PARP Inhibitor, on Growth in Human Tumor Cell Lines With Defective DNA Damage Response Pathways

The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair mechanisms...

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Detalles Bibliográficos
Publicado en:Oncol Res
Main Authors: Mini, Enrico, Landini, Ida, Lucarini, Laura, Lapucci, Andrea, Napoli, Cristina, Perrone, Gabriele, Tassi, Renato, Masini, Emanuela, Moroni, Flavio, Nobili, Stefania
Formato: Artigo
Idioma:Inglês
Publicado: Cognizant Communication Corporation 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841208/
https://ncbi.nlm.nih.gov/pubmed/28429680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/096504017X14926854178616
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