The Inhibitory Effects of HYDAMTIQ, a Novel PARP Inhibitor, on Growth in Human Tumor Cell Lines With Defective DNA Damage Response Pathways

The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair mechanisms...

Full description

Saved in:
Bibliographic Details
Published in:Oncol Res
Main Authors: Mini, Enrico, Landini, Ida, Lucarini, Laura, Lapucci, Andrea, Napoli, Cristina, Perrone, Gabriele, Tassi, Renato, Masini, Emanuela, Moroni, Flavio, Nobili, Stefania
Format: Artigo
Language:Inglês
Published: Cognizant Communication Corporation 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841208/
https://ncbi.nlm.nih.gov/pubmed/28429680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3727/096504017X14926854178616
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items