mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation

A master coordinator of cell growth, mTORC1 is activated by different metabolic inputs, particularly the metabolism of glutamine (glutaminolysis), to control a vast range of cellular processes, including autophagy. As a well-recognized tumour promoter, inhibitors of mTORC1 such as rapamycin have bee...

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Udgivet i:Nat Commun
Main Authors: Villar, Victor H., Nguyen, Tra Ly, Delcroix, Vanessa, Terés, Silvia, Bouchecareilh, Marion, Salin, Bénédicte, Bodineau, Clément, Vacher, Pierre, Priault, Muriel, Soubeyran, Pierre, Durán, Raúl V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264013/
https://ncbi.nlm.nih.gov/pubmed/28112156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14124
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