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mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
A master coordinator of cell growth, mTORC1 is activated by different metabolic inputs, particularly the metabolism of glutamine (glutaminolysis), to control a vast range of cellular processes, including autophagy. As a well-recognized tumour promoter, inhibitors of mTORC1 such as rapamycin have bee...
Zapisane w:
| Wydane w: | Nat Commun |
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| Główni autorzy: | , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5264013/ https://ncbi.nlm.nih.gov/pubmed/28112156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14124 |
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