Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging

Low-complexity “prion-like” domains in key RNA-binding proteins (RBPs) mediate the reversible assembly of RNA granules. Individual RBPs harboring these domains have been linked to specific neurodegenerative diseases. Although their aggregation in neurodegeneration has been extensively characterized,...

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Publicado no:Cell Rep
Main Authors: Lechler, Marie C., Crawford, Emily D., Groh, Nicole, Widmaier, Katja, Jung, Raimund, Kirstein, Janine, Trinidad, Jonathan C., Burlingame, Alma L., David, Della C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5263236/
https://ncbi.nlm.nih.gov/pubmed/28076789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.033
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