GABA(A) receptor occupancy by subtype selective GABA(Aα2,3) modulators: PET studies in humans

RATIONALE: Sedation, dependence, and abuse liability limit the use of non-selective γ-aminobutyric acid (GABA(A)) receptor positive modulators for the treatment of anxiety. AZD7325 and AZD6280 are novel, subtype-selective GABA(Aα2,3) receptor positive modulators with limited sedative effects. OBJECT...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Psychopharmacology (Berl)
Autori principali: Jucaite, Aurelija, Cselényi, Zsolt, Lappalainen, Jaakko, McCarthy, Dennis J., Lee, Chi-Ming, Nyberg, Svante, Varnäs, Katarina, Stenkrona, Per, Halldin, Christer, Cross, Alan, Farde, Lars
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2016
Soggetti:
Original Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5263201/
https://ncbi.nlm.nih.gov/pubmed/28013354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-016-4506-4
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