Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma

Aurora A Kinase (AURKA), a member of the serine/threonine kinase family, plays a critical role in cell division, and it is widely overexpressed in a variety of tumors including glioblastoma (GBM). Alisertib (MLN8237) is an orally administered selective AURKA inhibitor with potent antiproliferative a...

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Veröffentlicht in:J Neurooncol
Hauptverfasser: Kurokawa, C, Geekiyanage, H, Allen, C, Iankov, I, Schroeder, M, Carlson, B, Bakken, K, Sarkaria, J, Ecsedy, JA, D’Assoro, A, Friday, B, Galanis, E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5263047/
https://ncbi.nlm.nih.gov/pubmed/27816996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-016-2285-8
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