Intra-tumor delivery of zoledronate mitigates metastasis-induced osteolysis superior to systemic administration

Bisphosphonates (BPs) have recently been shown to have direct anti-tumor properties. Systemic treatment with BPs can have multiple adverse effects such as osteonecrosis of the jaw and BP induced bone fracturing and spine instability. While benefits of systemic BP treatments may outweigh risks, local...

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Detalhes bibliográficos
Publicado no:J Bone Oncol
Main Authors: Nooh, Anas, Zhang, Yu Ling, Sato, Daisuke, Rosenzweig, Derek H., Tabariès, Sébastien, Siegel, Peter, Barralet, Jake E., Weber, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5262502/
https://ncbi.nlm.nih.gov/pubmed/28138422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbo.2017.01.001
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