The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development

Voltage-gated sodium channels (VGSC) regulate neuronal excitability by governing action potential (AP) generation and propagation. Recent studies have revealed that AMP-activated protein kinase (AMPK) activators decrease sensory neuron excitability, potentially by preventing sodium (Na(+)) channel p...

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Udgivet i:PLoS One
Main Authors: Asiedu, Marina N., Han, Chongyang, Dib-Hajj, Sulayman D., Waxman, Stephen G., Price, Theodore J., Dussor, Gregory
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261566/
https://ncbi.nlm.nih.gov/pubmed/28118359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169882
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