The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development

Voltage-gated sodium channels (VGSC) regulate neuronal excitability by governing action potential (AP) generation and propagation. Recent studies have revealed that AMP-activated protein kinase (AMPK) activators decrease sensory neuron excitability, potentially by preventing sodium (Na(+)) channel p...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Asiedu, Marina N., Han, Chongyang, Dib-Hajj, Sulayman D., Waxman, Stephen G., Price, Theodore J., Dussor, Gregory
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261566/
https://ncbi.nlm.nih.gov/pubmed/28118359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169882
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires