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Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development
HAND2 is an ancestral regulator of heart development and one of four transcription factors that control the reprogramming of fibroblasts into cardiomyocytes(1–4). Deletion of Hand2 in mice results in right ventricle hypoplasia and embryonic lethality(1,5). Hand2 expression is tightly regulated by up...
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| Udgivet i: | Nature |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5261552/ https://ncbi.nlm.nih.gov/pubmed/27783597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature20128 |
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