Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells

Besides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (TERT) may promote tumorigenesis through extra-telomeric functions. The possible therapeutic effects of BIBR1532 (BIBR), a powerful TERT inhibitor, have been evaluated in different cellular backgrounds, but no data...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Celeghin, Andrea, Giunco, Silvia, Freguja, Riccardo, Zangrossi, Manuela, Nalio, Silvia, Dolcetti, Riccardo, De Rossi, Anita
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260987/
https://ncbi.nlm.nih.gov/pubmed/28032863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.425
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