Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia

Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome region maintenance 1 homolog (CRM1) interacting natural product avrainvillamide (A...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Andresen, Vibeke, Erikstein, Bjarte S, Mukherjee, Herschel, Sulen, André, Popa, Mihaela, Sørnes, Steinar, Reikvam, Håkon, Chan, Kok-Ping, Hovland, Randi, McCormack, Emmet, Bruserud, Øystein, Myers, Andrew G, Gjertsen, Bjørn T
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260983/
https://ncbi.nlm.nih.gov/pubmed/27906185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.392
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