Preclinical Profile of a Potent γ-Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties

Notch signaling is an area of great interest in oncology. RO4929097 is a potent and selective inhibitor of γ-secretase, producing inhibitory activity of Notch signaling in tumor cells. The RO4929097 IC(50) in cell-free and cellular assays is in the low nanomolar range with >100-fold selectivity w...

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Vydáno v:Cancer Res
Hlavní autoři: Luistro, Leopoldo, He, Wei, Smith, Melissa, Packman, Kathryn, Vilenchik, Maria, Carvajal, Daisy, Roberts, John, Cai, James, Berkofsky-Fessler, Windy, Hilton, Holly, Linn, Michael, Flohr, Alexander, Jakob-Røtne, Roland, Jacobsen, Helmut, Glenn, Kelli, Heimbrook, David, Boylan, John F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260798/
https://ncbi.nlm.nih.gov/pubmed/19773430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1843
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