Discovery of siRNA Lipid Nanoparticles to Transfect Suspension Leukemia Cells and Provide In Vivo Delivery Capability

As a powerful research tool, siRNA's therapeutic and target validation utility with leukemia cells and long-term gene knockdown is severely restricted by the lack of omnipotent, safe, stable, and convenient delivery. Here, we detail our discovery of siRNA-containing lipid nanoparticles (LNPs) a...

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Detalhes bibliográficos
Main Authors: He, Wei, Bennett, Michael J, Luistro, Leopoldo, Carvajal, Daisy, Nevins, Thomas, Smith, Melissa, Tyagi, Gaurav, Cai, James, Wei, Xin, Lin, Tai-An, Heimbrook, David C, Packman, Kathryn, Boylan, John F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916034/
https://ncbi.nlm.nih.gov/pubmed/24002693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.210
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