Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes

Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease characterized by the loss of lower motor neurons. SBMA is caused by expansions of a polyglutamine tract in the gene coding for androgen receptor (AR). Expression of polyglutamine-expanded AR causes damage to motor neurons and skele...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Milioto, Carmelo, Malena, Adriana, Maino, Eleonora, Polanco, Maria J., Marchioretti, Caterina, Borgia, Doriana, Pereira, Marcelo Gomes, Blaauw, Bert, Lieberman, Andrew P., Venturini, Roberta, Plebani, Mario, Sambataro, Fabio, Vergani, Lodovica, Pegoraro, Elena, Sorarù, Gianni, Pennuto, Maria
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5259768/
https://ncbi.nlm.nih.gov/pubmed/28117338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41046
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