Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy

Spinal and bulbar muscular atrophy (SBMA) is characterized by loss of motoneurons and sensory neurons, accompanied by atrophy of muscle cells. SBMA is due to an androgen receptor containing a polyglutamine tract (ARpolyQ) that misfolds and aggregates, thereby perturbing the protein quality control (...

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Rusmini, Paola, Polanco, Maria Josefa, Cristofani, Riccardo, Cicardi, Maria Elena, Meroni, Marco, Galbiati, Mariarita, Piccolella, Margherita, Messi, Elio, Giorgetti, Elisa, Lieberman, Andrew P., Milioto, Carmelo, Rocchi, Anna, Aggarwal, Tanya, Pennuto, Maria, Crippa, Valeria, Poletti, Angelo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614888/
https://ncbi.nlm.nih.gov/pubmed/26490709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15174
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