Immunoglobulin and T-cell receptor gene high-throughput sequencing quantifies minimal residual disease in acute lymphoblastic leukemia and predicts post-transplant relapse and survival

Minimal residual disease (MRD) quantification is an important predictor of outcome after treatment for acute lymphoblastic leukemia (ALL). Bone marrow ALL burden ≥ 10(−4) after induction predicts subsequent relapse. Likewise, MRD ≥ 10(−4) in bone marrow prior to the initiation of conditioning for al...

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Detalhes bibliográficos
Publicado no:Biol Blood Marrow Transplant
Main Authors: Logan, Aaron C., Vashi, Nikita, Faham, Malek, Carlton, Victoria, Kong, Katherine, Buno, Ismael, Zheng, Jianbiao, Moorhead, Martin, Klinger, Mark, Zhang, Bing, Waqar, Amna, Zehnder, James L., Miklos, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5259557/
https://ncbi.nlm.nih.gov/pubmed/24769317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2014.04.018
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