Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia

The ability to distinguish clonal B-cell populations based on the sequence of their rearranged immunoglobulin heavy chain (IgH) locus is an important tool for diagnosing B-cell neoplasms and monitoring treatment response. Leukemic precursor B cells may continue to undergo recombination of the IgH ge...

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Detalhes bibliográficos
Main Authors: Gawad, Charles, Pepin, Francois, Carlton, Victoria E. H., Klinger, Mark, Logan, Aaron C., Miklos, David B., Faham, Malek, Dahl, Gary, Lacayo, Norman
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507147/
https://ncbi.nlm.nih.gov/pubmed/22932801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-429811
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