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Serial segmental duplications during primate evolution result in complex human genome architecture

The human genome is particularly rich in low-copy repeats (LCRs) or segmental duplications (5%–10%), and this characteristic likely distinguishes us from lower mammals such as rodents. How and why the complex human genome architecture consisting of multiple LCRs has evolved remains an open question....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Genome Res
Hauptverfasser: Stankiewicz, Paweł, Shaw, Christine J., Withers, Marjorie, Inoue, Ken, Lupski, James R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525679/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15520286/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gr.2746604
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