Genome Architecture Catalyzes Nonrecurrent Chromosomal Rearrangements

To investigate the potential involvement of genome architecture in nonrecurrent chromosome rearrangements, we analyzed the breakpoints of eight translocations and 18 unusual-sized deletions involving human proximal 17p. Surprisingly, we found that many deletion breakpoints occurred in low-copy repea...

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Main Authors: Stankiewicz, Paweł, Shaw, Christine J., Dapper, Jason D., Wakui, Keiko, Shaffer, Lisa G., Withers, Marjorie, Elizondo, Leah, Park, Sung-Sup, Lupski, James R.
Format: Artigo
Language:Inglês
Published: The American Society of Human Genetics 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180264/
https://ncbi.nlm.nih.gov/pubmed/12649807
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