Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

BACKGROUND: Pancreatic cancer is characterised by the accumulation of a fibro-inflammatory stroma. Within this stromal reaction, myeloid cells are a predominant population. Distinct myeloid subsets have been correlated with tumour promotion and unmasking of anti-tumour immunity. OBJECTIVE: The goal...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Zhang, Yaqing, Velez-Delgado, Ashley, Mathew, Esha, Li, Dongjun, Mendez, Flor M, Flannagan, Kevin, Rhim, Andrew D, Simeone, Diane M, Beatty, Gregory L, Pasca di Magliano, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
Assuntos:
Pancreas
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256390/
https://ncbi.nlm.nih.gov/pubmed/27402485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-312078
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