Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

BACKGROUND: Pancreatic cancer is characterised by the accumulation of a fibro-inflammatory stroma. Within this stromal reaction, myeloid cells are a predominant population. Distinct myeloid subsets have been correlated with tumour promotion and unmasking of anti-tumour immunity. OBJECTIVE: The goal...

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Bibliographische Detailangaben
Veröffentlicht in:Gut
Hauptverfasser: Zhang, Yaqing, Velez-Delgado, Ashley, Mathew, Esha, Li, Dongjun, Mendez, Flor M, Flannagan, Kevin, Rhim, Andrew D, Simeone, Diane M, Beatty, Gregory L, Pasca di Magliano, Marina
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2017
Schlagworte:
Pancreas
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256390/
https://ncbi.nlm.nih.gov/pubmed/27402485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-312078
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