Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

Deregulated extracellular signal-regulated kinase (ERK) signaling drives cancer growth. Normally, ERK activity is self-limiting by the rapid inactivation of upstream kinases and delayed induction of dual-specificity MAP kinase phosphatases (MKPs/DUSPs). However, interactions between these feedback m...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Kidger, Andrew M., Rushworth, Linda K., Stellzig, Julia, Davidson, Jane, Bryant, Christopher J., Bayley, Cassidy, Caddye, Edward, Rogers, Tim, Keyse, Stephen M., Caunt, Christopher J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5255582/
https://ncbi.nlm.nih.gov/pubmed/28053233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614684114
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