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Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin

To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression do...

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Bibliografiske detaljer
Main Authors: Keller, Charles, Hansen, Mark S., Coffin, Cheryl M., Capecchi, Mario R.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC525541/
https://ncbi.nlm.nih.gov/pubmed/15520281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1243904
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