Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin

To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression do...

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Detalles Bibliográficos

Publicado en:	Genes Dev
Principais autores:	Keller, Charles, Hansen, Mark S., Coffin, Cheryl M., Capecchi, Mario R.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Cold Spring Harbor Laboratory Press 2004
Assuntos:	Research Communications
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525541/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15520281/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1243904
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