Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

The serine protease HtrA2/Omi is released from the mitochondrial intermembrane space following apoptotic stimuli. Once in the cytosol, HtrA2/Omi has been implicated in promoting cell death by binding to inhibitor of apoptosis proteins (IAPs) via its amino-terminal Reaper-related motif, thus inducing...

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Detalhes bibliográficos
Main Authors: Martins, L. Miguel, Morrison, Alastair, Klupsch, Kristina, Fedele, Valentina, Moisoi, Nicoleta, Teismann, Peter, Abuin, Alejandro, Grau, Evelyn, Geppert, Martin, Livi, George P., Creasy, Caretha L., Martin, Alison, Hargreaves, Iain, Heales, Simon J., Okada, Hitoshi, Brandner, Sebastian, Schulz, Jörg B., Mak, Tak, Downward, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC525490/
https://ncbi.nlm.nih.gov/pubmed/15509788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.22.9848-9862.2004
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