Enhanced HtrA2/Omi Expression in Oxidative Injury to Retinal Pigment Epithelial Cells and Murine Models of Neurodegeneration

PURPOSE: To investigate the role of HtrA2/Omi, a nuclear-encoded mitochondrial serine protease with a proapoptosis function, under H(2)O(2)-induced oxidative stress in human RPE, in the Ccl2(−/−) Cx3cr1(−/−) double-knockout (DKO) mouse retina, and the HtrA2/Omi-deficient mice. METHODS: Oxidative str...

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Detalhes bibliográficos
Main Authors: Ding, Xiaoyan, Patel, Mrinali, Shen, Defen, Herzlich, Alexandra A., Cao, Xiaoguang, Villasmil, Rafael, Klupsch, Kristina, Tuo, Jingsheng, Downward, Julian, Chan, Chi-Chao
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903625/
https://ncbi.nlm.nih.gov/pubmed/19443712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.09-3381
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