Synergism between Amodiaquine and Its Major Metabolite, Desethylamodiaquine, against Plasmodium falciparum In Vitro

The in vitro activity of the prodrug amodiaquine and its metabolite monodesethyl-amodiaquine has been studied for three strains of Plasmodium falciparum: LS-2, LS-3, and LS-1. Both compounds showed significant activity against all three strains; the activity of amodiaquine was slightly higher than t...

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Main Authors: Mariga, S. T., Gil, J. P., Sisowath, C., Wernsdorfer, W. H., Björkman, A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Susceptibility
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC525449/
https://ncbi.nlm.nih.gov/pubmed/15504826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.11.4089-4096.2004
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