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The impact of microRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells

MicroRNAs act posttranscriptionally to suppress multiple target genes within a cell population. To what extent this multi-target suppression occurs in individual cells and how it impacts transcriptional heterogeneity and gene co-expression remains unknown. Here we used single-cell sequencing combine...

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發表在:Nat Commun
Main Authors: Gambardella, Gennaro, Carissimo, Annamaria, Chen, Amy, Cutillo, Luisa, Nowakowski, Tomasz J., di Bernardo, Diego, Blelloch, Robert
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253645/
https://ncbi.nlm.nih.gov/pubmed/28102192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14126
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