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Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells

Translation and mRNA degradation are intimately connected, yet the mechanisms that link them are not fully understood. Here, we studied these mechanisms in embryonic stem cells (ESCs). Transcripts showed a wide range of stabilities, which correlated with their relative translation levels and that di...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Freimer, Jacob W, Hu, TJ, Blelloch, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086665/
https://ncbi.nlm.nih.gov/pubmed/30044225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38014
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