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Distinct responses of compartmentalized glutathione redox potentials to pharmacologic quinones targeting NQO1
Deoxynyboquinone (DNQ), a potent novel quinone-based antineoplastic agent, selectively kills solid cancers with overexpressed cytosolic NAD(P)H:quinone oxidoreductase-1 (NQO1) via excessive ROS production. A genetically encoded redox-sensitive probe was used to monitor intraorganellar glutathione re...
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| Udgivet i: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5253246/ https://ncbi.nlm.nih.gov/pubmed/27986568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.12.082 |
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