Distinct responses of compartmentalized glutathione redox potentials to pharmacologic quinones targeting NQO1

Deoxynyboquinone (DNQ), a potent novel quinone-based antineoplastic agent, selectively kills solid cancers with overexpressed cytosolic NAD(P)H:quinone oxidoreductase-1 (NQO1) via excessive ROS production. A genetically encoded redox-sensitive probe was used to monitor intraorganellar glutathione re...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochem Biophys Res Commun
Prif Awduron: Kolossov, Vladimir L., Ponnuraj, Nagendraprabhu, Beaudoin, Jessica N., Leslie, Matthew T., Kenis, Paul J., Gaskins, H. Rex
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253246/
https://ncbi.nlm.nih.gov/pubmed/27986568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.12.082
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