Conditionally Replicating Adenoviruses Kill Tumor Cells via a Basic Apoptotic Machinery-Independent Mechanism That Resembles Necrosis-Like Programmed Cell Death

Conditionally replicating adenoviruses (CRAds) represent a promising class of novel anticancer agents that are used for virotherapy. The E1AΔ24 mutation-based viruses, Ad5-Δ24 [CRAd(E3−); E3 region deleted] and infectivity-enhanced Ad5-Δ24RGD [CRAd(E3+)] have been shown to potently eradicate tumor c...

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Main Authors: Abou El Hassan, Mohamed A. I., van der Meulen-Muileman, Ida, Abbas, Saman, Kruyt, Frank A. E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC525077/
https://ncbi.nlm.nih.gov/pubmed/15507611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.22.12243-12251.2004
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