Emergence of a Drug-Dependent Human Immunodeficiency Virus Type 1 Variant during Therapy with the T20 Fusion Inhibitor

The fusion inhibitor T20 belongs to a new class of anti-human immunodeficiency virus type 1 (HIV-1) drugs designed to block entry of the virus into the host cell. However, the success of T20 has met with the inevitable emergence of drug-resistant HIV-1 variants. We describe an evolutionary pathway t...

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Hlavní autoři: Baldwin, Chris E., Sanders, Rogier W., Deng, Yiqun, Jurriaans, Suzanne, Lange, Joep M., Lu, Min, Berkhout, Ben
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC525057/
https://ncbi.nlm.nih.gov/pubmed/15507629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.22.12428-12437.2004
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