Increased Multinucleoside Drug Resistance and Decreased Replicative Capacity of a Human Immunodeficiency Virus Type 1 Variant with an 8-Amino-Acid Insert in the Reverse Transcriptase

Resistance to antiretroviral drugs is generally conferred by specific amino acid substitutions, rather than insertions or deletions, in reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1). The exception to these findings is the amino acid insertions found in the β3-β4 loop of t...

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Detalhes bibliográficos
Main Authors: van der Hoek, Lia, Back, Nicole, Jebbink, Maarten F., de Ronde, Anthony, Bakker, Margreet, Jurriaans, Suzanne, Reiss, Peter, Parkin, Neil, Berkhout, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1075723/
https://ncbi.nlm.nih.gov/pubmed/15731248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.6.3536-3543.2005
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