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Increased Multinucleoside Drug Resistance and Decreased Replicative Capacity of a Human Immunodeficiency Virus Type 1 Variant with an 8-Amino-Acid Insert in the Reverse Transcriptase

Resistance to antiretroviral drugs is generally conferred by specific amino acid substitutions, rather than insertions or deletions, in reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1). The exception to these findings is the amino acid insertions found in the β3-β4 loop of t...

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Main Authors: van der Hoek, Lia, Back, Nicole, Jebbink, Maarten F., de Ronde, Anthony, Bakker, Margreet, Jurriaans, Suzanne, Reiss, Peter, Parkin, Neil, Berkhout, Ben
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1075723/
https://ncbi.nlm.nih.gov/pubmed/15731248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.6.3536-3543.2005
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