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Vpr and Vpu Are Important for Efficient Human Immunodeficiency Virus Type 1 Replication and CD4(+) T-Cell Depletion in Human Lymphoid Tissue Ex Vivo

The relevance of the accessory vpr, vpu, and nef genes for human immunodeficiency virus type 1 (HIV-1) replication in human lymphoid tissue (HLT), the major site of viral replication in vivo, is largely unknown. Here, we show that an individual deletion of nef, vpr, or vpu significantly decreases HI...

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Bibliografiske detaljer
Main Authors: Rücker, Elke, Grivel, Jean-Charles, Münch, Jan, Kirchhoff, Frank, Margolis, Leonid
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC525056/
https://ncbi.nlm.nih.gov/pubmed/15507658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.22.12689-12693.2004
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