De Novo Initiation Pocket Mutations Have Multiple Effects on Hepatitis C Virus RNA-Dependent RNA Polymerase Activities

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) has several distinct biochemical activities, including initiation of RNA synthesis by a de novo mechanism, extension from a primed template, nontemplated nucleotide addition, and synthesis of a recombinant RNA product from two or more n...

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Bibliographic Details
Main Authors: Ranjith-Kumar, C. T., Sarisky, R. T., Gutshall, L., Thomson, M., Kao, C. C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC525054/
https://ncbi.nlm.nih.gov/pubmed/15507607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.22.12207-12217.2004
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