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Terminal Nucleotidyl Transferase Activity of Recombinant Flaviviridae RNA-Dependent RNA Polymerases: Implication for Viral RNA Synthesis

Recombinant hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) was reported to possess terminal transferase (TNTase) activity, the ability to add nontemplated nucleotides to the 3′ end of viral RNAs. However, this TNTase was later purported to be a cellular enzyme copurifying with the HCV R...

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Autors principals: Ranjith-Kumar, C. T., Gajewski, J., Gutshall, L., Maley, D., Sarisky, R. T., Kao, C. Cheng
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC115107/
https://ncbi.nlm.nih.gov/pubmed/11507207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.18.8615-8623.2001
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