Terminal Nucleotidyl Transferase Activity of Recombinant Flaviviridae RNA-Dependent RNA Polymerases: Implication for Viral RNA Synthesis

Recombinant hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) was reported to possess terminal transferase (TNTase) activity, the ability to add nontemplated nucleotides to the 3′ end of viral RNAs. However, this TNTase was later purported to be a cellular enzyme copurifying with the HCV R...

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Autores principales: Ranjith-Kumar, C. T., Gajewski, J., Gutshall, L., Maley, D., Sarisky, R. T., Kao, C. Cheng
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC115107/
https://ncbi.nlm.nih.gov/pubmed/11507207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.18.8615-8623.2001
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