New Class of Orthopoxvirus Antiviral Drugs That Block Viral Maturation

By using a homology-based bioinformatics approach, a structural model of the vaccinia virus (VV) I7L proteinase was developed. A unique chemical library of ∼51,000 compounds was computationally queried to identify potential active site inhibitors. The resulting biased subset of compounds was assayed...

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Detalhes bibliográficos
Main Authors: Byrd, Chelsea M., Bolken, Tove' C., Mjalli, Adnan M., Arimilli, Murty N., Andrews, Robert C., Rothlein, Robert, Andrea, Tariq, Rao, Mohan, Owens, Katrina L., Hruby, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC525040/
https://ncbi.nlm.nih.gov/pubmed/15507601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.22.12147-12156.2004
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