Reduction of Hepatitis C Virus NS5A Hyperphosphorylation by Selective Inhibition of Cellular Kinases Activates Viral RNA Replication in Cell Culture

Efficient replication of hepatitis C virus (HCV) subgenomic RNA in cell culture requires the introduction of adaptive mutations. In this report we describe a system which enables efficient replication of the Con1 subgenomic replicon in Huh7 cells without the introduction of adaptive mutations. The s...

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Main Authors: Neddermann, Petra, Quintavalle, Manuela, Di Pietro, Chiara, Clementi, Angelica, Cerretani, Mauro, Altamura, Sergio, Bartholomew, Linda, De Francesco, Raffaele
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC524975/
https://ncbi.nlm.nih.gov/pubmed/15542681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.13306-13314.2004
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