Polo-Like Kinase 1 Is Involved in Hepatitis C Virus Replication by Hyperphosphorylating NS5A

Hepatitis C virus (HCV) replication involves many viral and host factors. Here, we employed a lentivirus-based RNA interference (RNAi) screening approach to search for possible cellular factors. By using a kinase-phosphatase RNAi library and an HCV replicon reporter system, we identified a serine-th...

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Detalhes bibliográficos
Main Authors: Chen, Yung-Chia, Su, Wen-Chi, Huang, Jing-Ying, Chao, Ti-Chun, Jeng, King-Song, Machida, Keigo, Lai, Michael M. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916529/
https://ncbi.nlm.nih.gov/pubmed/20534861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00068-10
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