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Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver

The hepatitis C virus nonstructural protein NS5A is involved in resistance to the host immune response, as well as the viral lifecycle such as replication and maturation. Here, we established transgenic mice expressing NS5A protein in the liver and examined innate immune responses against lipopolysa...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Tsutsumi, Takeya, Okushin, Kazuya, Enooku, Kenichiro, Fujinaga, Hidetaka, Moriya, Kyoji, Yotsuyanagi, Hiroshi, Aizaki, Hideki, Suzuki, Tetsuro, Matsuura, Yoshiharu, Koike, Kazuhiko
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5249188/
https://ncbi.nlm.nih.gov/pubmed/28107512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170461
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