Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver

The hepatitis C virus nonstructural protein NS5A is involved in resistance to the host immune response, as well as the viral lifecycle such as replication and maturation. Here, we established transgenic mice expressing NS5A protein in the liver and examined innate immune responses against lipopolysa...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Tsutsumi, Takeya, Okushin, Kazuya, Enooku, Kenichiro, Fujinaga, Hidetaka, Moriya, Kyoji, Yotsuyanagi, Hiroshi, Aizaki, Hideki, Suzuki, Tetsuro, Matsuura, Yoshiharu, Koike, Kazuhiko
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5249188/
https://ncbi.nlm.nih.gov/pubmed/28107512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170461
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