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Upon Accounting for the Impact of Isoenzyme Loss, Gene Deletion Costs Anticorrelate with Their Evolutionary Rates

System-level metabolic network models enable the computation of growth and metabolic phenotypes from an organism’s genome. In particular, flux balance approaches have been used to estimate the contribution of individual metabolic genes to organismal fitness, offering the opportunity to test whether...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jacobs, Christopher, Lambourne, Luke, Xia, Yu, Segrè, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5249160/
https://ncbi.nlm.nih.gov/pubmed/28107392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170164
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