An Approach to Elucidate NBS1 Function in DNA Repair Using Frequent Nonsynonymous Polymorphism in Wild Medaka (Oryzias latipes) Populations

Nbs1 is one of the genes responsible for Nijmegen breakage syndrome, which is marked with high radiosensitivity. In human NBS1 (hNBS1), Q185E polymorphism is known as the factor to cancer risks, although its DSB repair defect has not been addressed. Here we investigated the genetic variations in med...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Igarashi, Kento, Kobayashi, Junya, Katsumura, Takafumi, Urushihara, Yusuke, Hida, Kyohei, Watanabe-Asaka, Tomomi, Oota, Hiroki, Oda, Shoji, Mitani, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5249114/
https://ncbi.nlm.nih.gov/pubmed/28107384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170006
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