An Approach to Elucidate NBS1 Function in DNA Repair Using Frequent Nonsynonymous Polymorphism in Wild Medaka (Oryzias latipes) Populations

Nbs1 is one of the genes responsible for Nijmegen breakage syndrome, which is marked with high radiosensitivity. In human NBS1 (hNBS1), Q185E polymorphism is known as the factor to cancer risks, although its DSB repair defect has not been addressed. Here we investigated the genetic variations in med...

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Publicat a:PLoS One
Autors principals: Igarashi, Kento, Kobayashi, Junya, Katsumura, Takafumi, Urushihara, Yusuke, Hida, Kyohei, Watanabe-Asaka, Tomomi, Oota, Hiroki, Oda, Shoji, Mitani, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5249114/
https://ncbi.nlm.nih.gov/pubmed/28107384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170006
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