Mechanical Stress and Single Nucleotide Variants Regulate Alternative Splicing of the MYLK Gene

The nonmuscle (nm) myosin light-chain kinase isoform (MLCK), encoded by the MYLK gene, is a vital participant in regulating vascular barrier responses to mechanical and inflammatory stimuli. We determined that MYLK is alternatively spliced, yielding functionally distinct nmMLCK splice variants inclu...

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Bibliographic Details
Published in:Am J Respir Cell Mol Biol
Main Authors: Mascarenhas, Joseph B., Tchourbanov, Alex Y., Fan, Hanli, Danilov, Sergei M., Wang, Ting, Garcia, Joe G. N.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2017
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248959/
https://ncbi.nlm.nih.gov/pubmed/27529643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0053OC
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