PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers

The spleen tyrosine kinase (SYK) regulates immune cell activation in response to engagement of a variety of receptors, making it an intriguing target for the treatment of inflammatory and autoimmune disorders as well as certain B‐cell malignancies. We have previously reported on the discovery and pr...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Pharmacol
Hauptverfasser: Coffey, Greg, Rani, Aradhana, Betz, Andreas, Pak, Yvonne, Haberstock‐Debic, Helena, Pandey, Anjali, Hollenbach, Stanley, Gretler, Daniel D., Mant, Tim, Jurcevic, Stipo, Sinha, Uma
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Pharmacodynamics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248591/
https://ncbi.nlm.nih.gov/pubmed/27406873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.794
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