Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis

BACKGROUND: Selective disruption of the spleen tyrosine kinase (Syk) represents a novel strategy to control B-cell functional responses by inhibition of B-cell antigen receptor (BCR) signaling. PRT062607 (P505-15) is a highly selective small molecule Syk inhibitor that potently suppresses B-cell fun...

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Bibliografiska uppgifter
Huvudupphovsmän: Coffey, Greg, Betz, Andreas, Graf, Jonathan, Stephens, Gillian, Hua Lin, Pei, Imboden, John, Sinha, Uma
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Publishing Ltd 2013
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186432/
https://ncbi.nlm.nih.gov/pubmed/25505569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.16
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