Is there a role of synovial biopsy in drug development?

по Filkova, Maria, Cope, Andrew, Mant, Tim, Galloway, James
Опубликовано в: BMC Musculoskelet Disord (2016)

Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies

по Baluom, Muhammad, Grossbard, Elliott B, Mant, Tim, Lau, David T W
Опубликовано 2013

Pharmacokinetics and Tolerability of the Novel Oral Prostacyclin IP Receptor Agonist Selexipag

по Kaufmann, Priska, Okubo, Kaori, Bruderer, Shirin, Mant, Tim, Yamada, Tetsuhiro, Dingemanse, Jasper, Mukai, Hideya
Опубликовано в: Am J Cardiovasc Drugs (2015)

Comparison of the pharmacokinetics, safety, and immunogenicity of MSB11022, a biosimilar of adalimumab, with Humira(®) in healthy subjects

по Hyland, Elizabeth, Mant, Tim, Vlachos, Pantelis, Attkins, Neil, Ullmann, Martin, Roy, Sanjeev, Wagner, Volker
Опубликовано в: Br J Clin Pharmacol (2016)

Maximum Tolerated Dose Evaluation of the AMPA Modulator Org 26576 in Healthy Volunteers and Depressed Patients: A Summary and Method Analysis of Bridging Research in Support of Pha...

по Nations, Kari R., Bursi, Roberta, Dogterom, Peter, Ereshefsky, Larry, Gertsik, Lev, Mant, Tim, Schipper, Jacques
Опубликовано 2012

Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteo...

по Gow, Jason M., Tsuji, Wayne H., Williams, Gary J., Mytych, Daniel, Sciberras, David, Searle, Shawn L., Mant, Tim, Gibbs, John P.
Опубликовано в: Arthritis Res Ther (2015)

Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clini...

по Martin, Paul, Gillen, Michael, Millson, David, Oliver, Stuart, Brealey, Clive, Grossbard, Elliott B., Baluom, Muhammad, Lau, David, Sweeny, David, Mant, Tim, Craven, Kelli
Опубликовано в: Drugs R D (2016)

PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers

по Coffey, Greg, Rani, Aradhana, Betz, Andreas, Pak, Yvonne, Haberstock‐Debic, Helena, Pandey, Anjali, Hollenbach, Stanley, Gretler, Daniel D., Mant, Tim, Jurcevic, Stipo, Sinha, Uma
Опубликовано в: J Clin Pharmacol (2016)

Pegylated, full-length, recombinant factor VIII for prophylactic and on-demand treatment of severe hemophilia A

по Konkle, Barbara A., Stasyshyn, Oleksandra, Chowdary, Pratima, Bevan, David H., Mant, Tim, Shima, Midori, Engl, Werner, Dyck-Jones, Jacqueline, Fuerlinger, Monika, Patrone, Lisa, Ewenstein, Bruce, Abbuehl, Brigitt
Опубликовано в: Blood (2015)

Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants

по Maden, Charlotte H., Fairman, David, Chalker, Michelle, Costa, Maria J., Fahy, William A., Garman, Nadia, Lukey, Pauline T., Mant, Tim, Parry, Simon, Simpson, Juliet K., Slack, Robert J., Kendrick, Stuart, Marshall, Richard P.
Опубликовано в: Eur J Clin Pharmacol (2018)

Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran—Results of the phase 1 inhibitor cohort

по Pasi, K. John, Lissitchkov, Toshko, Mamonov, Vasily, Mant, Tim, Timofeeva, Margarita, Bagot, Catherine, Chowdary, Pratima, Georgiev, Pencho, Gercheva‐Kyuchukova, Liana, Madigan, Kate, Van Nguyen, Huy, Yu, Qifeng, Mei, Baisong, Benson, Craig C., Ragni, Margaret V.
Опубликовано в: J Thromb Haemost (2021)

Pharmacokinetic equivalence, comparable safety, and immunogenicity of an adalimumab biosimilar product (M923) to Humira in healthy subjects

по Hillson, Jan, Mant, Tim, Rosano, Molly, Huntenburg, Carolyn, Alai‐Safar, Mehrshid, Darne, Siddhesh, Palmer, Donna, Pavlova, Borislava G., Doralt, Jennifer, Reeve, Russell, Goel, Niti, Weilert, Doris, Rhyne, Paul W., Chance, Kamali, Caminis, John, Roach, James, Ganguly, Tanmoy
Опубликовано в: Pharmacol Res Perspect (2018)